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激素性股骨头坏死遗传易感性的研究进展 被引量：14

Advances in researches on genetic predisposition to steroid-induced osteonecrosis of the femoral head
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摘要 激素性股骨头坏死的发病机制目前尚未明确,近年来的研究表明激素性股骨头坏死患者的发病与遗传易感因素有关。本文就激素代谢、转运、抵抗和激素受体基因以及血液凝溶系统、脂肪代谢、骨代谢的相关基因多态性与股骨头坏死对激素敏感性的关联研究概况予以综述,讨论了研究的有关问题及对策,并就研究前景进行了展望。 The pathogenesis of steroid induced osteonecrosis of the femoral head（SONFH） is not very clear at present. For the past few years researches showed that the SONFH related to genetic predisposing factors. The related research progresses were reviewed in this article to show the correlation between genetic mutation and genetic polymorphism of steroid metabolism and transport,resistance and receptor,coagulation and fibrinolysis,lipid and bone metabolism and susceptibility to SONFH. The article also discussed current problems,countermeasure and future applications.
作者 曾平 韦标方 何伟 苏式兵
机构地区 临沂市人民医院博士后科研工作站 广州中医药大学博士后科研流动站 临沂市人民医院骨科 广州中医药大学第一附属医院骨科 上海中医药大学中医复杂系统研究中心
出处 《中国骨伤》 CAS 2010年第2期156-159,共4页 China Journal of Orthopaedics and Traumatology
基金 国家自然科学基金(编号:30672700) 山东省博士后创新项目专项基金(编号:200803013)
关键词 股骨头坏死 糖皮质激素 遗传易感性 基因多态性 Femur head necrosis Glucocorticoid Genetic susceptibility Gene polymorphism
分类号 R681.8 [医药卫生—骨科学]
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参考文献29

  • 1Jones LC,Hungerford DS. Osteonecrosis:etiology,diagnosis,and treatment. Curr Opin Rheumatol, 2004,16 (4) :443-449.
  • 2Hadjigeorgiou G, Dardiotis E, Dardioti M, et al. Genetic association studies in osteonecrosis of the femoral head:mini review of the literature. Skeletal Radiol,2008,37:1-7.
  • 3Hsieh KP,Lin YY,Cheng CL,et al. Novel mutations of CYP3A4 in Chinese. Drug Metab Dispos, 2001,29 (3) : 268-273.
  • 4Kaneshiro Y,Oda Y,Iwakiri K,et al. Low hepatic cyctochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis. Clin Pharmacol Ther, 2006,80 : 396-402.
  • 5Kaneshiro Y,Takaoka K. Hepatic CYP3A activity in association with development of osteonecrosis of the femoral head. Clin Calcium,2007,17 : 902-909.
  • 6Asano T,Takahashi KA, Fujioka M,et al. Genetic analysis of steroid- induced osteonecrosis of the femoral head. J Orthop Sci,2003,8 (3) :329-333.
  • 7Tamura K,Nakajima S,Hirota Y,et al. Genetic association of a polymorphism of the cAMP-responsive element binding proteinbinding protein with steroid- induced osteonecrosis after kidney transplantation. J Bone Miner Metab, 2007,25 : 320-325.
  • 8Sakaeda T, Nakamura T, Okumura K. MDR 1 genotype-related pharmacokinetics and pharmacodynamics. Biol Pharm Bull,2002,25 ( 11 ) : 1391-1400.
  • 9Asano T,Takahashi KA,Fujioka M,et al. ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteoneerosis of the femoral head after kidney transplantation. Pharmacogenetics, 2003,13 ( 11 ) : 675-682.
  • 10Van Rossum EF, Roks PH, De Jong FH, et al. Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms. Clin Endocrinol (Oxf), 2004,61 (5) :573-581.

二级参考文献61

  • 1叶平,陈保生,王士雯.载脂蛋白B基因可变数目串联重复序列多态性及其与冠心病关联的研究[J].中国病理生理杂志,1996,12(1):4-9. 被引量：8
  • 2Cakirer B, Hans G, Graham J, et al. The relationship between craniofacial morphology and obstructive sleep apnea in whites and in African-Americans. Am J Respir Crit Care Med, 2001,163:947 -950.
  • 3Schwab R J, Pasirstein M, Pierson A, et al. Identification of upper airway anatomy risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med, 2003,168:522-530.
  • 4Schwab RJ. Genetic determinations of upper airway structures that predispose to obstructive sleep apnea.Respir Physiol Neurobiol, 2005, 147:289 - 298.
  • 5Thomas RJ, Terzano MG, Parrino L, et al. Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern-a recognizable polysomnographic variant with practical clinical implications. Sleep,2004,27: 229 - 234.
  • 6Younes M. Role of arousals in the pathogenesis of obstructive sleep apnea. Am J Respir Crit Care Med, 2004, 169:623 - 633.
  • 7Palmer LJ, Buxbaum SG, Larkin E, et al. A whole genome scan for obstructive sleep apnea and obesity. Am J Hum Genet, 2003,72:340 -350.
  • 8Tsuchiya T, Shimizu H, Horie T, et al. Expression of leptin receptors in lung: leptin as a growth factor. Europ J Pharmacol, 1999,365:273- 229.
  • 9Larkin EK, Elston RC, Patel SR, et al. Linkage of serum leptin levels in families with sleep apnea. Int J Obs, 2005,29:260-267.
  • 10Sinton CM, Fitch TE, Gershenfeld HK, et al. The effects of leptin on REM sleep and slow wave delta in rats are reversed by food deprivation.J Sleep Res, 1999,197 - 203.

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二级引证文献105

中国骨伤
2010年 第2期

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