活性大红3G的合成研究

A Study on the Synthesis of Reactive Scarlet 3G

以2,4-二氨基苯磺酸钠、2,3-二溴丙酰氯和γ酸为原料,经酰化、重氮化、偶合和盐析制得活性大红3G。重点研究了两步酰化过程。通过实验得到了较完整的反应条件:酰化温度0～15℃,pH控制在5～7.5,2,3-二溴丙酰氯与2,4-二氨基苯磺酸钠的投料比是1.05∶1;2,3-二溴丙酰氯与γ酸的投料比也是1.05∶1,酰化收率达90%以上。

Reactive Searlet 3G was prepared from sodium 2, 4-diaminobenzenesulfonate, 2, 3-dibromopropanoyl chloride and γacid by acylation, diazotization, coupling and salting-out. The two steps of aeylation were studied emphatically. The complete reaction conditions were obtained by experiments： the temperature of acylation was 0 - 15 ℃, pH was controlled between 5 -7.5 ; the molar ratio of 2, 3-dibromopropanoyl chloride and sodium 2, 4-diaminobenzenesulfonate was 1.05： 1, 2, 3-dibromopropanoyl chloride and γ acid molar ratio was 1.05： 1. The yield of aeylation was above 90%.