血脂、体质量指数与受体双阴性乳腺癌预后关系的临床研究

Relationship of Blood Lipid Level and Body Mass Index with Prognosis of Breast Cancer Patients with Both Estrogen Receptor and Progesterone Receptor Negative

【目的】观察乳腺癌患者术前血脂、体质量指数(BMI)与乳腺癌预后的关系。【方法】通过随访乳腺癌巩固期受体双阴性患者,比较手术前血脂、BMI正常患者与血脂、BMI异常患者短期复发转移率与病死率的差异。【结果】血脂异常组复发转移率与病死率明显高于血脂正常组(P<0.05),BMI≥25的患者复发转移病死率大于BMI<25的患者(P<0.05)。【结论】血脂升高及体质量增加与乳腺癌的预后不良存在相关性。

Objective To explore the relationship of blood lipid level and body mass index （BMI） with prognosis of breast cancer patients with both estrogen receptor （ER） and progesterone receptor （PR） negative. Methods A follow-up was carried oat in breast cancer patients with both ER and PR negative during the period of consolidating the therapeutic effect. The recrudescence and metastasis rate and the fatality rate in patients with normal blood lipid level and BMI before operation were compared with those in patients with abnormal blood lipid level and BMI. Results The recrudescence and metastasis rate and the fatality rate in patients with abnormal blood lipid level and BMI were higher than those in the patients with normal blood lipid level and BMI （P 〈 0. 05 ）, and were the highest in patients with BMI ≥25 （P 〈 0.05 compared with those patients with BMI 〈 25）. Conclusion The correlation is shown between the prognosis of breast cancer patients and the increase of blood lipid level and BMI.