红细胞中微量元素含量与甲状腺功能的关系

THE RELATIONSHIP OF ELEMENT CONTENTS IN ERYTHROCYTE WITH THYROID FUNCTION

采用体外放射分析法、质子激发Ｘ荧光和中子活化分析方法测定了７６例甲状腺疾病患者的甲状腺功能和红细胞中微量元素的含量。结果表明：甲低、正常、亚甲亢和甲亢４个组之间微量元素Ｋ、Ｃａ、Ｃｕ、Ｓｅ、Ｒｂ、Ｆｅ的含量无显著性差异；Ｚｎ的含量甲低组显著地高于甲亢和亚甲亢组，正常组则介于甲低与甲亢和亚甲亢组之间；甲低和正常组Ｋ、Ｚｎ、Ｃｕ的含量与Ｔ３、Ｔ４浓度比及ＴＳＨ浓度有显著相关；甲亢和亚甲亢组Ｓｅ的含量与Ｔ４、ＴＳＨ浓度有较显著相关。提示微量元素含量与甲状腺功能的不同状态密切相关。

The serum thyroid hormones(T 3,T 4,TSH,FT 3 and FT 4) level and the elements K, Ca, Fe, Cu, Zn, Se and Rb in the erythrocyte in 76 cases is measured by radiometric assay in vitro (RIA and IRMA) and nuclear analytical technique (PIXE and INNA). According to thyroid hormones level, the cases are divided into four groups with hyperthyroid, normal, sub hyperthyroid and hypothyroid. The difference and correlation of various parameters in four groups are compared by Oneway ANOVA and Partial Correlation using SPSS/PC statistical package respectively. The results show that the content of Zn for hypothyroid group is significantly higher than hyperthyroid( P =0.007) and sub hyperthyroid( P =0.046) groups, and the content of Zn for normal is lower than hypothyroid group but not significant difference ( P =0.083),the other elements contents are no significant difference among four groups. The highly significant linear correlation between the contents of K, Zn and Cu in the erythrocyte and T 3、T 4 level ratio and TSH level is observed in hypothyroid and normal groups, the close correlation between the content of Se and serum T 4 and TSH level is also observed in hyperthyroid and sub hyperthyroid groups. These suggest that trace elements may be important for the synthesis, metabolism and biological function of thyroid hormones.