首发精神分裂症患者认知功能的研究

The study of First-episode schizophrenia cognitive function

目的:研究首发精神分裂症患者的认知功能损害程度及范围。方法:选取我院2005年1月至2008年10月门诊及住院的首发精神分裂症患者52例、选取我院职工45例为对照组,采用修订韦氏成人智力测验(WAIS-RC)、修订韦氏记忆量表(WMS-R)、字色串扰测验(StroopTest)、连线测验(Trail MakingTest,TMT)、HANOI塔(HANOI Tower)、威斯康星卡片分类测验-改良版(M-WCST),从智力、记忆力、注意力、执行功能进行对照分析。结果:智力测验患者组与对照组有极显著性差异(P<0.001),记忆测验患者组与对照组差异有统计学意义(P<0.05),注意测验患者组与对照组有极显著性差异(P<0.001);执行功能患者组与对照组之间各项均存在极显著性差异(P<0.001)。结论:首发精神分裂症患者在有关智力、注意、记忆、言语功能和执行功能等神经认知功能领域存在广泛的损害。

Objective：To study the damage and range of First -episode schizophrenia cognitive function. Methods：A total of 52 First - episode schizophrenias from our hospital outpatients and inpatients from January 2005 to October 2008. A total of 45 employ- ees of hospital are the collator. The subjects were investigated with YWAIS - RC, WMS - R, Stroop Test, Trail Making Test （TMT）, HANOI Tower, M -WCST. Results： There is significant difference between the team of patient with collator in intelligence test, executive function test and attention test. There is statistical significance between the team of patient with collator in memory test. Conclusions： The results show that First - episode schizophrenias have broad damage in neural cognitive functions of intelligent, attention, memory, verbal function and executive function.