肾病综合征型妊娠期高血压疾病50例临床分析

Clinical analysis on 50 cases with nephrotic syndrome combined with hypertensive disorder complicating pregnancy

目的:分析肾病综合征型妊娠期高血压疾病(NSP)的临床特点及其对孕妇及新生儿的影响。方法:比较50例NSP患者(NSP组)与117例妊娠期高血压患者(对照组)的血压、眼底改变、生化指标及母婴的并发症。结果:NSP组的发病时间早于对照组,腹水、重度水肿发生率高于对照组(P<0.05),总胆固醇、血清白蛋白、24 h尿蛋白定量及尿素氮的异常表现较对照组突出(P<0.01),新生儿窒息率明显高于对照组,体重和1 min Apgar评分明显低于对照组(P<0.01)。结论:NSP病情重,对母婴影响大,尤其是对新生儿影响较大。适时终止妊娠可以减少患者的妊娠期并发症,同时也可以减少新生儿的发病率和死亡率。

Objective：To analyze the clinical characteristics and effect of nephrotic syndrome combined with hypertensive disorder complicating pregnancy（NSP） on pregnant women and neonates.Methods：The blood pressure,fundus changes,biochemical markers and complications of mothers and neonates of 50 cases with NSP（NSP group） and 117 cases with hypertensive disorder complicating pregnancy（control group） were compared.Results：The onset time of NSP group was earlier than that of control group,the incidences of ascites and severe edema in NSP group was higher that of control group（P0.05）,the change ranges of levels of total cholesterol,serum albumin,24 hours urinary protein and blood urea nitrogen in NSP group were larger than those in control group（P0.01）,the incidence of neonatal asphyxia in NSP group was higher than that in control group,but the body weight and 1 minute Apgar score in NSP group was significantly lower than that in control group（P0.01）.Conclusion：Patients with NSP are severe,and NSP has a great impact on mothers and infants,especially for neonates.Timely termination of pregnancy can reduce complications during pregnancy,neonatal morbidity and mortality.