C-erbB-2、ER、PR在乳腺浸润性导管癌中的表达及意义

Expression levels and significance of C-erbB-2,ER and PR in patients with invasive breast ductal carcinoma

目的:探讨乳腺浸润性导管癌中ER、PR和C-erbB-2的表达,并分析其相关性。方法:应用免疫组化方法,检测60例乳腺浸润性导管癌患者中ER、PR和C-erbB-2的表达情况。结果:ER、PR和C-erbB-2的阳性表达率分别为58.3%(35/60)、41.7%(25/60)和40.0%(24/60);ER与PR表达之间差异有统计学意义(P<0.05);ER与C-erbB-2表达之间差异无统计学意义(P>0.05);PR与C-erbB-2表达之间差异无统计学意义(P>0.05)。结论:C-erbB-2和ER、PR可能是乳腺癌预后指标的独立因子,但C-erbB-2表达与ER、PR关系有待研究。ER、PR在乳腺癌中的表达有相关性。

Objective：To explore the expression levels and correlation of estrogen receptor（ER）,progestogen receptor（PR） and C-erbB-2 in patients with invasive breast ductal carcinoma.Methods：The expression levels of ER,PR and C-erbB-2 in 60 patients with invasive breast ductal carcinoma were detected by immunohistochemical method.Results：The positive expression rates of ER,PR and C-erbB-2 were 58.3 %（35/60）,41.7 %（25/60） and 40.0%（24/60）,respectively.There was significant difference between ER and PR（P0.05）.There was no significant difference between ER and C-erbB-2（P0.05）.There was no significant difference between PR and C-erbB-2（P0.05）.Conclusion：C-erbB-2,ER and PR are possibly independent factors of prognosis of breast carcinoma,but the relationship between C-erbB-2 expression and ER,PR needs more researches,there is correlation between ER expression and PR expression in breast carcinoma.