辛伐他汀对2型糖尿病合并冠心病患者血清淀粉样蛋白A的影响

The effect of simvastatin on A-SAA in patients with T2DM and coronary disease

目的探讨辛伐他汀对2型糖尿病合并冠心病患者血清淀粉样蛋白A(A-SAA)的影响。方法2型糖尿病无冠心病患者16例;2型糖尿病合并冠心病患者34例,合并冠心病组又分为非辛伐他汀治疗组16例,辛伐他汀治疗组18例。分别治疗12周,治疗前后均检测血生化及A-SAA等指标。结果2型糖尿病合并冠心病患者的A-SAA水平较无冠心病组高;治疗12周后3组患者的甘油三酯(TG)、总胆固醇(TC)和SAA水平均较治疗前降低(P<0.05),高密度脂蛋白胆固醇(HDL-c)显著升高(P<0.01)。结论辛伐他汀降低TC,升高HDL之外,还可以通过降低A-SAA水平来发挥其抗动脉粥样硬化作用。

Objective To investigate the effect of simvastatin on the acute phase serum amyloid protein A（A-SAA） in patients with coronary disease and type 2 diabetes mellitus.Methods The subjects included 16 patients with type 2 diabetes mellitus but with no coronary disease（group A） and 34 patients complicated with both type 2 diabetes mellitus and coronary disease,who were further divided into non-simvastatin treatment group（group B,n=16） and simvastatin treatment group（group C,n=18）.All the patients underwent treatment for 12 weeks and their levels of plasma lipids and A-SAA were measured before and after the treatment.Results At the end of the treatment,the A-SAA levels in groups B and C were higher than those in group A;the levels of total chloesterol（TC）,triglyceride（TG） and A-SAA decreased and the levels of high density lipoprotein cholesterol（HDL-c） significantly increased（P0.01）.Conclusion In addition to its effects of decreasing TC and increasing HDL,simvastatin can exert its anti-atherosclerotic effect by reducing the expression of A-SAA.