新生儿先天性甲状腺功能减低症发病趋势分析

Analysis on the trend of neonatal congenital hypothyroidism in Lianyungang city

目的:分析新生儿先天性甲状腺功能减低症(Congenital hypothyroidism,CH)发病趋势及影响因素。方法:①收集文献报道的全国,上海历年CH年发病率。②连云港市新生儿CH诊断标准按卫生部《新生儿疾病筛查技术规范》进行。结果:连云港市2000年实施新生儿筛查,CH年发病率2003～2006年为1/2322,较2000～2002年的1/4601有显著上升(P<0.05),2007～2008年5月发病率为1/1422,较2003～2006年发病率差异有统计学意义(P<0.01)。1996年国家实施USI,上海统计1996年前后11年CH发病率从1/4603上升为1/3146(P<0.05)。全国CH年发病率从1998年前的1/5063上升到1998～2002年的1/2359,2003～2006年发病率继续有所上升为1/1807(P<0.01)。结论:国内近年CH发病率上升是否系部分个体碘营养缺乏或过量导致子代CH发病率上升。

Objective： To analyze the trend and effects of neonatal congenital hypothyroidism （CH） Methods： （1）To collect countrywide and Shanghai＇s incidences of congenital hypothyroidism. （2）The criterion of diagnosing CH accorded with 《The technical criterion of neonatal screening》 . Results： Since 2000 year, filtering neonatal disease was put in practice, the incidence of CH showed marked raise （P 〈0. 05）, that were 1/4 601 from 2000 to 2002, corresponding to 1/2322 of 2003 to 2006. Furthermore, it was 1/1422 during 2007 to 2008. that was notably different from the incidence of 2003 to 2006 （P 〈 0. 01 ） . According to the statistic, since government carried out the universal salt iodination, the incidences of CH went up from 1/4 603 to 1/3 146 （ P 〈 0. 05 ） in Shanghai during 11 years former and after 1996. Furthermore, in countrywide that went up from 1/5063 before 1998 to 1/2 359 in 1998 -2002, and 1/1 807 in 2003 -2006 （P 〈 0. 01） Conclusion： The incidence of neonatal congenital hypothyroidism raise recently, that may result from scanty or excessively iodine taking.