摘要
目的:探讨促血管生成素2(angiopoietin-2,Ang2)基因1087G/A位点基因多态性与卵巢癌的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对158例卵巢癌患者和160例健康对照者的Ang2基因1087G/A位点基因型进行检测。结果:Ang2基因1087G/A位点基因型频率和等位基因频率在两组人群中的分布差异无统计学意义(P>0.05)。结论:Ang2基因1087G/A位点基因多态性可能与卵巢癌发生无关。
Objective： To explore the relationship between polymorphism of angiopoietin -2 （Ang2） gene and ovarian carcinoma. Methods： Genotypes of 1087G/A sites in Ang2 gene from 158 patients with ovarian carcinoma and 160 healthy women were detected by polymerase chain reactionrestriction fragment length polymorphism （PCR -RFLP） . Results： There was no significant difference in frequency of genotypes and alleles of 1087G/A sites in Ang2 gene between ovarian carcinoma patients and healthy women （ P 〉 0. 05） . Conclusion： There is no correlation between polymorphism ofl087G/A sites in Ang2 gene and ovarian carcinoma possibly.
出处
《中国妇幼保健》
CAS
北大核心
2010年第8期1094-1095,共2页
Maternal and Child Health Care of China
关键词
An舀基因
卵巢癌
基因多态性
相关性
Angiopoietin - 2
Ovarian carcinoma
Gene polynmrphism
Correlation
