合成β-胸苷氢化反应中Raney Ni的优化

Optimization of Raney Ni in the Synthesis of β-thymidine

对合成β-胸苷的加氢除溴RaneyNi催化剂进行通氢预处理,研究了各种条件活化的影响。结果表明,最佳活化时间为6h、活化和反应温度为20℃、压力为0.2MPa,经过活化的催化剂6次重复使用时仍具有较强的催化效果。对RaneyNi催化剂进行通氢预处理,既可以提高收率,又抑制副反应的进行,并且增加了催化剂的重复利用次数,节约成本,易于工业化生产。

Hydrogenation is made on the catalyst Raney Ni in the synthesis of β-thymidine to remove bromine,activation impact under all kinds of conditions are studied.Results show that the best activation time is 6 h,activation and reaction temperatures are both 20 ℃,pressure is 0.2 MPa.The activated catalyst after it is used 6 times has still good catalyzing effect.Hydrogenation pretreatment on Raney Ni can not only raise the yield,restrain the side reaction,but also increase the repetitive use times,save the cost,which facilitates the industrialization production.