Nrf2在多器官保护中的作用研究进展

Role of Nrf2 in multi-organ protection

细胞需要面对包含活性氧族和亲电子剂等多种微环境损害,它们通过多种机制应对有毒或致癌物质的损伤。其中最重要的细胞防御机制是通过转录因子Nrf2(nuclear factor-erythroid 2 p45-related factor 2)调节的。大量的研究均证实,Nrf2能够抵御广谱的毒性物质和致病原对细胞的损伤。Nrf2介导的细胞保护反应无细胞特异性和器官特异性,Nrf2可保护肺脏、肝脏、消化道、神经系统和心血管系统等多种器官或组织。因此,Nrf2在多器官保护中具有巨大的治疗潜力。

Since cells constantly encounter various microenvironment insults induced by reactive oxygen species or electrophiles,they have evolved defense mechanisms to cope with these injuries. One of the most important cellular defense mechanisms is mediated by the transcription factor Nrf2. Numerous studies have shown that Nrf2 protects many cell types and organ systems, including lung, liver, digestive gut, neural system, cardiovascular system, and so on,from a broad spectrum of toxic insults and disease pathogenesis in a cell or organ independent way. The widespread nature of Nrf2 may have an important therapeutic potential in multi-organ protection.