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化疗对B细胞非霍奇金淋巴瘤患者CD_4^+CD_(25)^+Foxp_3^+Treg细胞的影响

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摘要 目的探讨B细胞非霍奇金淋巴瘤(B-NHL)的发病机制及化疗对B-NHL患者机体抗肿瘤免疫状态的影响。方法采用流式细胞术分别检测35例B-NHL患者(观察组)化疗前后及30例健康对照者(对照组)外周血中CD4+CD25+Treg细胞所占比例,RT-PCR法检测各组外周血中转录因子Foxp3 mRNA的相对表达水平。结果观察组化疗前后外周血CD4+CD25+Treg细胞的比例、Foxp3 mRNA表达均显著高于对照组,化疗后显著高于化疗前,P均<0.05。结论机体抗肿瘤免疫功能受抑是B-NHL患者发病原因之一;化疗在杀伤肿瘤细胞的同时亦可进一步削弱患者机体自身的抗肿瘤免疫功能。
作者 王海英 唐述森 王占聚 孙秀梅 唐瑛
机构地区 潍坊医学院附属医院
出处 《山东医药》 CAS 北大核心 2010年第11期58-59,共2页 Shandong Medical Journal
关键词 非霍奇金淋巴瘤 B细胞 CD4+CD25+Foxp3+Treg 化疗
分类号 R551.2 [医药卫生—血液循环系统疾病]
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参考文献6

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共引文献5

山东医药
2010年 第11期

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