高本底辐射对居民机体外周血SOD和MDA的影响

Effect of Natural High Background Radiation on SOD and MDA in the Peripheral Blood of Inhabitants

目的探讨小剂量慢性长期连续照射人群的抗氧化水平的改变。方法选择我国阳江天然放射性高本底辐射地区(HBRA)出生并长大的53名50～59岁男性居民作为研究对象,另选择恩平市横坡镇(CA)年龄相仿的男性居民作为对照人群。分别抽取他们外周血5ml,并测定血清中超氧化物歧化酶(SOD)活力、丙二醛(MDA)含量。结果在HBRA和CA人群血清中,SOD活力为(65.9±38.5)μ/ml、(50.2±26.2)μ/ml,MDA含量为(4.5±2.0)nmol/ml、(6.5±2.6)nmol/ml。与CA组相比,HBRA组人群SOD活力较高、MDA含量较低,差异均有统计学意义(P<0.05)。结论天然放射性高本底辐射(简称高本底辐射)可能对机体的抗氧化指标SOD和MDA有影响。

Objective To study the change of antioxygen level of those who are continuously exposed to light and chronic radiation. Methods 53 male inhabitants aged from 50 - 59 years are selected as the object of study , who are born and bred in Yanjiang high natural background radiation area 〈 HBRA 〉. Additional male inhabitants of similar ages in the town of Hengpi, Enping 〈 CA 〉 are chosen as the contrast group. 5ml of peripheral blood is separately drawn to determine the activity of superoxide dismutase 〈 SOD 〉 and the content of malondialdehyde 〈 MDA 〉 in the serum. Results In the serum of HBRA and CA groups, the activity of SOD is 〈65.9 ±38.5 〉 and （50.2 ±26.2）μ/ml respectively,and the content of MDA is （4.5 ± 2.0）nmol/ml and （6.5 ± 2.6） nmol/ml respectively. Compared with CA group , the activity of HBRA group is high. but its content of MDA is low. These differences are statistically significant（P 〈 0.05）. Conclusion Natural high background radiation could have an effect on the antioxidation indexes such as SOD and MDA.