长期吸入糖皮质醇激素治疗儿童哮喘的安全性研究进展

The Research Department of Safety about Childhood Asthma Treated by Hormone Cortisol

支气管哮喘是儿童最常见的慢性疾病,吸入激素仍是目前哮喘治疗最有效的方法。对于长期吸入糖皮质激素的哮喘儿童来说,中小剂量对身高、骨代谢、对下丘脑-垂体-肾上腺轴功能等几乎没有不良影响。高剂量可有明显的全身不良反应,包括肾上腺皮质功能抑制、骨质疏松和骨折危险增加。这些作用有剂量依赖关系,在治疗开始给予较大剂量糖皮质激素时,有可能对下丘脑-垂体-肾上腺轴功能、身高产生较强抑制作用。但在病情稳定并给予较小剂量后,影响逐渐消失,皮质醇又可以恢复到初诊时水平,不影响成年时的身高。

Bronchial asthma is the most common chronic diseases, asthma, inhaled corticosteroid therapy remains the most effective method,this article summarizes the long-term inhaled glucocorticoid Chol Su of the systemic impact and research progress, for long-term inhaled corticosteroids in asthmatic children speaking, small doses on height, bone metabolism, the hypothalamus-pituitary-adrenal axis functions almost no adverse effects. High doses can have significant systemic adverse reactions, including the adrenal cortex function inhibition, increased risk of osteoporosis and fractures. These effects are dose-dependent relationship in the beginning of treatment to give higher doses of glucocorticoids, it is possible pairs of the hypothalamus-pituitary-adrenal axis function, height produce strong inhibition. However,in a stable condition and to give smaller doses, the effect gradually disappeared, cortisol can also restored to the level when they first visit, does not affect adult height