曲美他嗪治疗老年慢性心功能不全60例疗效观察

The Effective Observation of Trimetazidine to Treat 60 Cases Chronic Cardic Insufficiency in Aged People

目的探讨曲美他嗪治疗老年慢性心功能不全的临床疗效。方法选择2008年4月至2009年5月在我院住院治疗的慢性心功能不全患者120例,将其随机分为观察组和对照组,各60例。对照组采用常规药物治疗,观察组在常规药物治疗的基础上加用曲美他嗪。治疗12周后,比较两组患者的疗效、心功能、心绞痛发作频率及持续时间、硝酸甘油用量。结果观察组治疗后总有效率为86.7%,对照组为66.7%,两组比较差异有统计学意义(P<0.05);且观察组治疗后疗效显著优于对照组(P<0.01)。治疗后两组患者心功能各指标间差异有统计学意义(P<0.05)。与对照组比较,观察组患者治疗后心绞痛发作频率、心绞痛持续时间和硝酸甘油用量均显著下降,差异有统计学意义(P<0.05)。结论在常规治疗的基础上加用曲美他嗪治疗老年慢性心力衰竭效果显著,能提高患者的心功能,且无严重不良反应,值得在临床推广应用。

Objective To explore the calinical effect of trimetazidine on chronic cardic insufficiency in aged people. Methods 120 cases of patients with chronic cardic insufficiency in our hospital from April 2008 to May 2009 were randomly divided into observation groups and control groups, there were 60 cases of patients in every groups, patients in control groups were treated with conventional therapy, patients in observation groups received additional drug treatment with trimetazidine on the base of conventional therapy, after twelve weeks, clinical effect,cardic function,attack frequency and duration of angina pectoris and total dose of nitruglycerol were contrast between observation groups and control groups. Results Total effective rate was 86.7% in observation groups and 66.7% in （P 〈 0.05 ） and therapeutic effect was preferable control groups, the difference has statistical significance in observation groups to in control groups（P 〈0.01 ） ; the differencein indicatrix of heart function in the two groups was significant in statistic （ P 〈 0.05 ）, in comparison with controls groups, attack frequency, duration of angina pectoris and total dose of nitroglycerol were notablely lower in observation groups, the difference was significant in statistic （ P 〈 0.05 ）. Conclusion Additional drug treatment with trimetazidine on the base of conventional therapy had notablely therapeutic efficacy on chronic cardic insufficiency in aged people and could improve heart function without severe adverse effect, that was valuable to clinical generalization.