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AMP激活的蛋白激酶及其对肉类生产的意义 被引量：3

Role of AMP-Activated Protein Kinase(AMPK) on Meat Production
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摘要 AMP激活的蛋白激酶(AMPK)广泛存在于真核生物细胞中,其活性主要受AMP/ATP比例的调节,AMPK可以通过控制ATP的合成和分解调节机体的能量代谢,是机体能量状态的传感器。作者综述了AMPK的结构、特点和活性调节,并对其在肉类生产中的应用前景进行了展望,AMPK调节糖酵解的深入研究有可能成为改善肉品质的有效靶点。 AMP-activated protein kinase（AMPK） is a kind of kinase that regulated by the AMP/ATP ratio and wildly exist in eukaryote cell.AMPK could regulate the energy metabolism through controlling the synthesis and decomposition of ATP,an index of energy state.In this review,the structure,characteristic and activity regulation of AMPK were summarized,furthermore,the potential application of it on meat production was also suggested.
作者 李泽 靳烨
机构地区 内蒙古农业大学食品科学与工程学院
出处 《食品与生物技术学报》 CAS CSCD 北大核心 2010年第1期9-13,共5页 Journal of Food Science and Biotechnology
基金 内蒙自治区科技厅科技专项(20050203)
关键词 AMPK 糖酵解 肉 品质 AMPK glycolysis meat quality
分类号 S852.23 [农业科学—基础兽医学]
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参考文献25

  • 1Shen QW, Gerrard DE, Du M, et al. An inhibitor of AMP-activated proteinkinase, inhibits glycolysis in mouse longissimus dorsi postmortem[J]. Meat Science, 2008,78: 323-330.
  • 2Hardie D G, Carling D. The AMP-activated protein kinase-fuel gauge of the mammalian cell? [J]. European Journal of Biochemistry, 1997,246(2): 259-273.
  • 3Hardie D G. AMP activated protein kinase: A key system mediating metabolic responses to exereise[J]. Medicine and Science in Sports and Exercise, 2004,36( 1 ): 28-34.
  • 4Shen Q W, Means W J, Thompson S A, et al. Pre slaughter transport, AMP-activated protein kinase, glycolysis, and quality of pork loin[J]. Meat Science, 2006,74:388 395.
  • 5Long Y C, Zierath J R. AMP-activated protein kinase signaling in metabolic regulation[J]. The Journal of Clinical Investigation, 2006,116(7) : 1776- 1783.
  • 6蔡明春,黄庆愿,高钰琪.AMPK与能量代谢[J].重庆医学,2005,34(1):120-122. 被引量：18
  • 7Gregory R S, Sebastian Beck Jogensen. The AMP-activated protein kinase: Role in regulation of skeletal muscle metabolism and insulin sensitivity[J]. Mini Reviews in Medicinal Chemistry, 2007,7(5): 521-528.
  • 8Horman S, Hussain N, Dilworth S M, et al. Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation[J]. Comparative Biochemistry and Physiology, 2005,142(8): 374-382.
  • 9Davies S P, Carling D, Hardie D G. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay[J]. European Journal of Biochemistry, 1989,186(1-2): 123-128.
  • 10Proszkowiec-Weglarz M, Richards M P, Ramachandran R, et al. Characterization of the AMP activated protein kinase pathway in chickens[J]. Comparative Biochemistry and Physiology, 2006,143( 1 ) : 92- 106.

二级参考文献108

  • 1吕进宏,刘华贵,马立保,徐淑芳.营养对肉鸡肉质影响的研究进展[J].动物科学与动物医学,2004,21(8):37-39. 被引量：14
  • 2经荣斌,宋成义,王宵燕.猪肌肉品质的影响因素及改善肉质的方法[J].动物科学与动物医学,2004,21(11):24-26. 被引量：7
  • 3刘振华.猪肉肉质特性生物化学研究进展[J].国外畜牧科技,1996,23(6):37-40. 被引量：33
  • 4殷仁富 胡晓月 等.低血流心肌缺血引起犬心肌葡萄糖转运蛋白向细胞膜移位[J].中华心血管病杂志,1999,27(6):428-428.
  • 5Zhou M.I。in BZ,Coughlin S,et a1.UCP-3 expression in skeletal muscle:effects of exercise,hypoxia,and AMP—activated protein kinase[J].Am J Physiol Endocrinol Metab.2000,279(3):E622.
  • 6Musi N,Fugii N,Hirshman MF,et a1.AMP activated protein kinase(AMPK)is activated in muscle of subjectswith type 2 diabetes during exercise[J].Diabetes,2001,50:921.
  • 7Bruce EK,Ken IM,David S,et a1.Dealing with energy demand:the AMP—activated protein kinase [J].Trends Biochem Sci,1999,24(1):22.
  • 8Cheung PC,Salt IP,Davies SP.Characterization of AMP—activated protein kinase gamma—subunit isoforms and their role in AMP binding[J].Biochem J,2000,346.(3):659.
  • 9Shamsadin R,Jantsan K,Adham I.Cloning,organisation,chromosomal localization and expression analysis of the mouse Prkagl gene[J].Cytogenet Cell Genet,2001,92(1—2):134.
  • 10I.ee GD Fryer,Asha Parbu Patel,David Carling.Protein kinase inhibitors block the stimulation of the AMP activated protein kinase by 5-amino-4-imidazolecarboxamide riboside[J].FEBS Letters,2002,531(2):189.

共引文献77

同被引文献55

  • 1蔡明春,黄庆愿,高钰琪.AMPK与能量代谢[J].重庆医学,2005,34(1):120-122. 被引量：18
  • 2司亚东,金有坤,周洪琪,陆桂.鲤鱼白肌中RNA/DNA值与其生长的关系[J].上海水产大学学报,1992,1(3):159-167. 被引量：35
  • 3王志祥,马秋刚,关舒,计成.地方鸡种固始鸡与快大型肉鸡肉质性状的比较研究[J].中国农业大学学报,2005,10(3):48-51. 被引量：18
  • 4宋庆文.动物脂肪代谢过程中关键酶的研究进展[J].畜牧与饲料科学,2007,28(3):58-60. 被引量：11
  • 5Adams J, Chen Z P,Van Denderen,et al.lntrasteric control of AMPK via the γ1 subunit AMP aUosteric regulatory site [J].Protein Sci, 2004,13,155-165.
  • 6Carling D,Hardie D G.The substrate and sequence specificity of the AMP - activated protein kinase PHospHoryhtion of glycogen synthase and phosphorylase kinase[J].Biochim Biophys Acta, 1989,1012 : 81 - 86.
  • 7Carling D,Clarke P K,Zammit V A,et al.Purification and characteriza- tion of the AMP-activated protein kimse [J].Eur J Biochem, 1989,186:129 - 136.
  • 8Davies S P, Carling D, Hardie D G.Tissue distribution of the AMP-acti- vated protein kinase, and lack of activation by cyclic-AMP-dependent proteinkinase ,studied using a specific and sensitive peptide assay [J].EUK J Biochem,. 1989,186,123 - 128.
  • 9Gillespie J G,Hardie D G.Phosphorylation and inactivation of HMG- CoA reductase at the AMP-activated protein kinase site in respome to fruc- rose treatment of isolated rat hepatocytes[J].FEBS Lett, 1992,306,59 - 62.
  • 10Hardie D G. (1992) Regulation of fatty acid and holesterol metabolism by the AMP-activated protein kinase,Biochim Biophys Acta,1123,231-238.

引证文献3

二级引证文献11

食品与生物技术学报
2010年 第1期

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