基于能量因子的基因调控网络重构

Reconstruction Gene Regulatory Network Depend on by Energy Factor

重构基因调控网络有助于探索生命系统的本质问题。线性组合模型以其形式简单和易于求解的特点被成功应用于基因网络的重构过程中。作者针对线性组合模型只考虑了基因之间的线性调控关系的缺陷,引入了能量因子的概念,从而使得模型具备了分析基因间的非线性调控关系的特性。将模型应用于大肠杆菌(Escherichia coli)的SOS DNA修复过程中,实验证明:该模型能较好地拟合大肠杆菌的SOS DNA修复过程,进一步提高了调控网络的构建精度。

Reconstruction of gene regulatory network can help to explore the essence of life.The Linear Combination Model has been successfully applied to the reconstruction of the gene regulator network,since it is very simple and can be easily solved.However,the linear relationships between genes were only considered in the model.In order to circumvent this problem,energy factor has been added in the Linear Combination Model,thus the new model can be used to analysis the nonlinear relationships between genes.Then the present model has been applied to reconstruct the gene regulatory network of Escherichia coli on SOS DNA repair process.Our result demonstrated that the proposed model can be reconstruct SOS DNA repair process well and also improve the accuracy.