自发性脑出血急性期血压水平与神经功能恢复的相关性研究

The relationship between neurologic rehabilitatet in spontaneous intracerebral hemorrhage and level of blood pressure

目的评估自发性脑出血患者急性期血压水平与早期神经功能恢复的相关性,比较以不同分界血压分组的各组患者神经功能恢复情况,探索最优目标血压。方法入选2004年1月至2006年4月期间,连续在华山医院神经内科病房住院,诊断为自发性脑出血,入院时距发病时间小于72h的患者,除外脑结构异常的患者,共92例完整病例资料,分析急性期血压与神经功能恢复间的相关性,并分别比较不同的分界血压下,各组患者神经功能恢复情况。结果收缩期血压与入院第28天神经功能恢复存在显著相关性。以160mmHg为界分组,收缩压≤160mmHg组患者神经功能恢复优于收缩压>160mmHg组。而以140mmHg和150mmHg为分界血压分组的两组患者第28天神经功能恢复在统计学上没有显著性差异。结论本研究认为自发性脑出血急性期血压水平若低于160mmHg,可能与28d神经功能恢复良好相关。

Objective To explore the possible proper aim of blood pressure for spontaneous intracerebral hemorrhage（SICH） and to compare the relationship between different boundaries of blood pressure and SICH prognosis. Methods We had 92 patients with ICH admitted within 72 hours of onset. Correlation analysis were performed to assess the reationship between neurologic impairment and systolic/diastolic blood pressure. Univariate analysis with different boundaries of blood pressure were performed respectively to determinethe possible proper aim of blood pressure. Results The 28-day neurologic impairment and systolic blood pressure has stastistical correlation. Patients with systolic blood pressure no more than 160mmHg had less neurologic impairment than those more than 160 mmHg （P 〈0.05）. While no statistics difference was found between two groups separated by 140 mmHg or 150 mmHg systolic blood pressure. Conclusion The results suggested that systolic bloodpressure in acute intracerebral hemorrhage under 160mmHg maybe related to better prognosis.