阿托伐他汀对急性心肌梗死患者心律失常的影响

The influence of atrovastatin on the patients with acute myocardial infarction and arrhythmia

目的为了探讨阿托伐他汀对急性心肌梗死患者并发心律失常的防治效果。方法133例急性心肌梗死（AMI）患者随机分为治疗组（67例）和对照组（66例），治疗组在急性心梗常规治疗基础上加用阿托伐他汀片（每晚服20mg，共6个月），对照组则加用烟酸缓释片（第一周每晚服0．5g，自第二周起每晚服1g，疗程相同）。结果治疗组患者发病6个月内，室性心律失常、房颤、心力衰竭、再发心绞痛和心肌梗死以及猝死发生率均明显低于对照组（P均〈0．05和0．01），同时治疗组患者治疗6个月后，血胆固醇（Tch）、低密度脂蛋白胆固醇（LDL-ch）、甘油三脂（TG）和脂蛋白a（Lpa）水平均明显低于对照组（P均〈0．01和0．05），而高密度脂蛋白胆固醇（HDL-ch）明显高于对照组（P〈0．01），两组患者治疗后结果与治疗前相比均显示出明显差异。结论阿托伐他汀可明显降低急性心梗患者心律失常和其他主要心脏事件的发生率，同时，显示出良好的调脂作用，安全性较好。

Objective To explore the efficiency of atrovastatin treating acute myocardial infarction（AMI）with arrhythmia. Methods A total of 133 cases patients with AMI and arrythmia were divided into two groups, treating group（67 eases）and control groups（66 cases）, the patient of treating group were treated by atrovastatin（20mg, q.n. total 6months）on the basic treatment for AMI, and the patient of control group were treated by Niaeia tablets（0.5g,q, n. in the first week, and 1.0g, q.n. in the following time）on the same basic treatment. Results The ratio of ventrieular arrhythmia,atrial fibrillation,heart failure,angina pectorils again and myocardial infarction again,sudden cardiac death in the treating group were significantly lower than the control group（ P 〈 0.05 and 0.01, too）, the same time, the level of Tch, LDL- ch, TG and Lpa in the treating group were lower apparently than the control group（ P 〈 0.05and 0.01, too）, but HDL- ch was higher than the later. The results in two groups after treatment was obvi- ously disparity than before treatment. Conclusion The ratio of arrhythmia and other primary cardiac matter in the patients with AMI were treated by atrovastatin were apprendy reduced, and the drug suit well in the patient with hyperlipemia, and it was safety drug.