摘要
目的:总结原发性胆汁性肝硬化(PBC)患者的临床表现、实验室检查,以提高对该病的认识。方法:回顾性分析61例PBC和50例非原发性胆汁性肝硬化(自身免疫性肝炎8例,乙型肝炎22例,丙型肝炎10例,酒精性肝炎10例)患者的临床资料。结果:①61例患者中女性55例(90.1%),男性6例(9.9%),性别比例差异具有统计学意义(P<0.01);②61例患者中无症状者35例(57.4%),有症状者26例(42.6%),主要表现为皮肤瘙痒、乏力、消瘦;③61例患者血清抗线粒体抗体100%阳性,和非原发性胆汁性肝硬化组相比,差异具有统计学意义(P<0.01);④ALP、TBA和r-GT明显升高,而ALT和AST呈轻中度升高,TBil呈轻度升高。结论:PBC是一种慢性自身免疫性疾病,临床工作者应该加强对患者PBC的认识,重视对血清抗线粒体抗体的检测,尤其是长期原因不明、肝功能异常的女性患者。
Objective:To summarize the clinical manifestations,laboratory examination in primary biliary cirrhosis(PBC),to raise awareness of the disease.Methods:Retrospective analysis was carried out on 61 cases with PBC and 50 patients with non-primary biliary cirrhosis(8 cases of autoimmune hepatitis,22 cases of hepatitis B,10 cases of hepatitis C,10 cas es of alcoholic hepatitis).Results:①Among the 61 patients,55 cases were female(90.1%),6 cases were male(9.9%),with a significant difference(P〈0.01);②Among 61 patients,35 cases(57.4%)were asymptomatic and 26 cases(42.6%) were symptoms,mainly for skin itching,fatigue and jaundice;③All of patients AMA were 100% positive and had a significant difference(P〈0.01),comparing with non-primary biliary cirrhosis;④ ALP,TBA and r-GT were significantly higher,while ALT and AST were moderately higher,TBil slightly higher.Conclusion:PBC is an autoimmune disease.Clinical workers should strengthen the awareness of PBC and attach importance to the AMA detection,particularly for the long-term unexplained female patients with abnormal liver function.
出处
《中国当代医药》
2010年第6期28-30,共3页
China Modern Medicine