不同血清低密度脂蛋白-胆固醇水平与冠心病患者预后的关系

The relationship of serum LDL-C level against the prognosis patients with coronary heart disease

目的:观察分析不同血清低密度脂蛋白-胆固醇(LDL-C)水平对冠心病患者预后的影响。方法:用消除法检测102例冠心病患者血清LDL-C水平,将其分为高水平组(3.02±0.35)mmol/L和低水平组(1.76±0.13)mmol/L,并对这两组患者进行随访,观察两组患者在随访期间心血管事件的发生率。结果:血清LDL-C水平高水平组(3.02±0.35)mmol/L明显高于低水平组(1.86±0.13)mmol/L,P<0.01。在随访期间,高水平组有17例发生心血管事件,发生率为32.69%,低水平组有1例发生心血管事件,发生率为2.08%,经χ2检验两组心血管事件发生率,差异有统计学意义(P<0.01),同时Logistic回归分析显示:血清LDL-C水平与患者预后密切相关。结论:冠心病患者应积极进行降脂治疗,将LDL-C水平降至2.0mmol/L以下临床获益更大。

Objective：To examin and analyze the influence to the prognosis of the patients with coronary heart disease,according to the levels of serum low density lipoprotein cholesterol（LDL-C）.Methods：The elimination method was used to test the levels of serum LDL-C of 102 patients with coronary heart disease.According to the test results,the patients were divided into the group with high level serum LDL-C（3.02±0.35）mmol/L and the group with low level serum LDL-C（1.76±0.13）mmol/L.All the patients were investigated in order to examin the probability of angiocardiopathy.Results：The probability of the group with high level serum LDL-C was obviously larger than that of the group with low level serum LDL-C.During the period of the investigation,17 angiocardiopathy cases were found in the group with high level serum LDL-C and the probability was 32.69%.While only one angiocardiopathy case was found in the group with low level serum LDL-C and the probability was 2.08%.The two test results were verified by χ2,the diference from each other was significant（P〈0.01）.Logistic regression analysis was finally used and the results showed that the prognosis of the patients with coronary heart disease was closely related with the level of serum LDL-C（P〈0.01）.Conclusion：Patients with coronary heart disease should receive the treatment to reduce fat.The clinical effect is significant when serum LDL-C is below 2.0 mmol/L.