盐酸美普他酚的合成研究

Study about the synthesis of meptazinol hydrochloride

目的:研究盐酸美普他酚的合成路线。方法:以3-甲氧基环己基-2-烯-酮为起始原料,经过对接、还原、烷基化及成盐等反应合成盐酸美普他酚。结果:总收率达20%。结论:此工艺路线反应步骤短,工艺简单,重结晶效果好,收率较高。

Objective：To study about the synthesis of Meptazinol Hydrochloride.Methods：The product Meptazinol Hydrochloride was Synthesized from starting materia 3-Methoxy-2-cyclohexen-1-one by docking,reduction,alkylation,sali fication.Results：Total yield is 20%.Conclusion：The advantage of the present synthetic route is that it has shorter reaction steps,convinient process,better crystalline effect and higher yield.