组织蛋白酶D在膀胱移行细胞癌中的表达及意义

EXPRESSION OF CATHEPSIN D IN HUMAN TRANSITIONAL CELL CARCINOMA OF BLADDER

为探讨组织蛋白酶D（CD）的表达与膀胱移行细胞癌（BTCC）生物学行为间关系，应用免疫组织化学ABC法，对33例BTCC及12例正常膀胱组织中CD抗原进行检测。结果显示：正常膀胱移行细胞均呈弱阳性表达，BTCC组肿瘤细胞强阳性率显著高于正常对照组（P＜0．05），且在不同病理分级、临床分期、单发与多发、初发与复发之间差异显著（P＜0．05）。提示CD表达与BTCC生物学特性密切相关，CD通过降解天然屏障在肿瘤浸润转移过程中起重要作用。

To evaluate the relationship between the expression of CD and bi0l0gical behaviour ofBTCC, 33 paraffin - embedded tissue specimens of BTCC were examined by the standard ABC immunohistochemical technique. The result revealed that all normal transitional cells were weakly stained and the5trongly positive rate of CD in BTCC was significantly higher than in normal control group (P < 0. 05).Pisher's accurate analysis showed that strongly positive expression of CD in tumour cells closely corrlatedwith different patholbgical grades (P < 0, 05), clinical stages (P <0. 05), number of lesions (P <0. 05), and postoperative reccurance (P < 0. 05). It was suggested that expression of CD closely cor-elated with grades and stages and it played the important role in the process of invasiveness and metastasisof BTCC by lowering the function of nature defences.