进展期胃癌术中区域化疗研究现状

Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer

目的探讨进展期胃癌术中区域化疗的可行性、安全性、有效性及其机理。方法复习国内、外相关文献并进行分析与综述。结果与全身化疗相比,进展期胃癌术中区域化疗可以增加肿瘤组织的药物浓度,降低全身性毒副反应,提高生存率,改善生存质量。结论术中区域化疗作为进展期胃癌的辅助手段已逐渐应用于临床,其疗效肯定,具有推广应用价值,但对其深入认识尚需更多的病例积累与系统研究。

Objective To explore the feasibility,safety,efficacy and mechanism of intraoperative regional chemotherapy of advanced gastric cancer. Methods The related literatures were reviewed and analyzed. Results Compared with systemic chemotherapy,intraoperative regional chemotherapy of advanced gastric cancer could increase blood drug concentration of cancerous tissue,reduce the systemic toxic side effects,increase survival rate and improve the quality of life. Conclusion Intraoperative regional chemotherapy,as an adjuvant treatment of advanced gastric cancer,has been gradually applied to clinic because of the definite curative effect,which is worth popularizing. However,it needs systemic researches and accumulation of cases.