摘要
Neuroinflammation has always been of concern in the pathogenesis of Alzheimer’s disease （AD）. As a major inflammatory mediator, prostaglandin E2 （PGE2） plays an important role in the inflammatory process of AD. Up to now, there is still controversy on the neuroprotective or neurotoxic role of PGE2. However, the role of PGE2 in neurodegeneration may be far more complex, due to the 4 EP receptor subtypes. This article aims to summarize the relationship between PGE2 receptor EP subtypes and AD. It is believed that a better understanding of the PGE2 receptor EP subtypes may help to clarify the relation between inflammation and AD, and to develop novel therapeutic strategies targeting specific EP receptor for AD treatment.
神经炎症在阿尔茨海默病(Alzheimer’sdisease,AD)发病机制中的作用一直备受关注。前列腺素E2(PGE2)作为一个主要的炎症介质,在AD的炎症过程中发挥着重要的作用。然而,目前关于PGE2对神经元是保护还是损害仍存有分歧。PGE2受体存在EP1-4四类亚型,因此要探讨PGE2在神经元损伤中扮演的角色,我们需综合考虑下游信号通路的作用。本文旨在综述PGE2受体EP亚型与AD的关系。对PGE2受体EP亚型的进一步研究将有助于阐明炎症与AD的联系,为AD治疗找到新的靶点。
基金
supported by grantsfrom the Natural Science Foundation of Zhejiang Province(No. Y206153)
the Science and Technology Major Projectsof Zhejiang Province (No. 2007C13053, 2008F80009)
the Science and Technology Programme of Hangzhou Munici-pality (No. 20051323B45)
