摘要
目的:观察人类白细胞相关抗原HLADR2、DRB10301、DQA10501基因频率与多发性肌炎/皮肌炎(PM/DM)发病及其临床表现的关系。方法:特异性引物聚合酶链式反应(PCRSSP)方法分别测定31例PM/DM患者及50例正常人的HLADR2、DRB10301及HLADQA10501的基因频率。结果:三种基因型在31例肌炎患者中基因频率分别为645%,968%和7742%,而在正常对照组的相应基因频率分别为32%,6%,22%;其中,HLADR2、HLADQA10501较正常对照均有显著性差异,HLADRB10301则无显著差异;肌炎患者中HLADQA10501等位基因携带者与不携带该基因者其临床表现无明显区别。
Objective:To compare the gene frequencies of HLA DR2、DRB1*0301、DQA1*0501 alleles with the pathogenesis and clinical manifestations of PM/DM.Methods:Thirty one PM/DM patients and 50 healthy control subjects were examined separately by PCR SSP to get the gene frequencies of the three alleles.Results:The gene frequency of HLA DR2 allele (6 45%) was much lower in PM/DM patients than that in normal subjects while the gene frequency of HLA DQA1*0501(77 42%) was much higher,the gene frequency of HLA DRB1*0301 had no difference between the two groups.Conclusion:HLA DR2 may play a protective role in the pathogenesis of PM/DM,while HLA DQA1*0501 is a risk factor of the diseases.
出处
《中华风湿病学杂志》
CAS
CSCD
1998年第4期208-210,共3页
Chinese Journal of Rheumatology