肝炎患者血清透明质酸、Ⅲ型前胶原氨基端尾肽、层粘蛋白与Ⅳ型胶原的检测及其临床意义

Significance of Serum HA, PⅢ NP, Ln and Ⅳ-C in Hepatitis

分析了166例肝病患者血清透明质酸（HA）、Ⅲ型前胶原氨基端尾肽（PⅢNP）、层粘蛋白（Ln）与Ⅳ型胶原（Ⅳ－C）。结果是：HA、PⅢNP、Ln在各型肝病人中血清含量均高于正常组（P＜0．01），IV－C在除急性肝炎组外的其余各组血清含量均高于正常组（P＜0．05）。而HA、PⅢNP、Ⅳ－C的含量，慢活肝、肝硬化组的病人高于慢迁肝组的病人（P＜0．01）。肝硬化组病人Ln高于慢迁肝组病人（P＜0．05）。HA、PⅢNP、Ⅳ-C、Ln与SB、ALB有相关性，而与ALT无关，慢活肝组病人PⅢNP平均值高于肝硬化组的病人。提示这些肝硬化指标在反映肝纤维化程度上有实用意义，似乎PⅢNP更能功态反映肝纤维化的程度。但这些肝纤维化指标在不同程度上受肝细胞损害的影响。

An analysis of serum hyaluronic acid(HA), amino terrminal propeptide of type Ⅲprocollagen(PⅢNP), laminin (Ln) and collagen type (Ⅳ-C) in 166 patients with various liverdiseases was made. The levels of HA, PⅢNP, Ln were increased in all patients with liver disease p < 0.01 )。Ⅳ- C was increasd in patients with liver disease except acute hepatitis ( P <0.05). The concentrations of HA, PⅢNP, Ⅳ- C in patients with CAH, LC were significantlyhigher than those with CPH ( P< 0.01 ). The Ln concentrations in patients with LC were higherthan those with CPH ( P<0.05).HA, PⅢNP,Ⅳ- C and Ln were positively correlated withSB,ALB.Therefore, the examination for serum HA, PⅢNP, Ln and Ⅳ- C in combination is asimple and reliable method in evaluating the degree of hepatic fibrosis, but those were related tohepatocellular damage.