人、猪和鸡血清中抗禽戊型肝炎病毒抗体的检测与鉴定

DETECTION AND CHARACTERIZATION OF HUMAN,SWINE,DUCK AND CHICKEN SERUM ANTIBODIES AGAINST AVIAN HEPATITIS E VIRUS

通过对人、猪和鸡血清中的抗禽戊型肝炎病毒（hepatitis E virus,HEV）ORF2抗体的检测以及对阳性血清抗体特异性的鉴定,本研究结果表明,人、猪和禽血清中抗禽HEVORF2抗体阳性率为0.91%~62.5%。因为禽与哺乳动物HEV ORF2抗原具有共有的抗原表位,而阳性血清中抗禽HEV ORF2特异性抗原表位抗体的阳性率为41.3%~92.1%,提示人、猪和鸡都有感染禽HEV的可能性,这为进一步验证禽HEV可能造成的人兽共感染提供新的科学依据。

This study described the serological investigation of avian hepatitis E by testing human,swine and chicken serum antibodies against avian hepatitis E virus（HEV） ORF2 and characterization of the serum antibody specificities.The results demonstrated that the positive rates of human,swine and chicken serum antibody against avian HEV ORF2 antigen were from 0.91% to 62.5%.Because avian and mammalian HEV ORF2 share common epitopes,and the positive rate of specific antibodies against avian HEV ORF2 epitopes were from 41.3% to 92.1%,these results suggested that human,swine and chicken could be infected by avian HEV and potential zoonosis of avian HEV.