慢性鼻-鼻窦炎基底膜厚度的观察

Investigation of basal membrane thickness in chronic rhinosinusitis

目的:观察慢性鼻-鼻窦炎筛窦黏膜中基底膜的厚度变化。方法:采用HE染色观察并测量10例对照组、35例慢性鼻-鼻窦炎不伴息肉(CRSsNP)及40例慢性鼻-鼻窦炎伴息肉(CRSwNP)和12例复发性CRS基底膜的厚度。结果:基底膜的厚度在对照组为(7.8±1.3)μm,CRSsNP组为(25.4±4.3)μm,CRSwNP组为(34.7±5.1)μm,复发组为(36.2±6.3)μm,与对照组比较,慢性鼻-鼻窦炎组及复发性CRS组的基底膜厚度有显著性差异(P<0.05)。结论:在慢性鼻-鼻窦炎中,基底膜增厚,尤其是在CRSwNP和复发性慢性鼻-鼻窦炎中,基底膜增厚更为明显。基底膜增厚在慢性鼻-鼻窦炎的发病机制中起重要作用,其意义有待进一步探讨。

Objective To investigate the changes of basal membrane thickness in ethmoid mucosa in chronic rhinosinusitis.Method Using HE staining to study basal membrane thickness in 10 cases of control group,35 cases of CRSsNP,40 cases of CRSwNP and 12 cases of recurrent CRS.Results The mean basal membrane thickness were（7.8±1.3）μm,（25.4±4.3）μm,（34.7±5.1）μm and（36.2±6.3）μm in control group,CRSsNP group,CRSwNP group and recurrent CRS group,respectively.Comparing with control group,the mean basal membrane thickness in CRS group and recurrent CRS group showed statistically significant difference（P0.05）.Conclusion Basal membrane is more thicker in CRS and recurrent CRS than in control group.Increased basal membrane thickness plays an important role in pathogenesis of CRS.