静脉注射脑利钠肽对急性冠脉综合征神经内分泌激素的影响

Effects of Neuroendocrine system of intravenous brain natriuretic peptide on neuroendocrine in patients with acute coronary syndrome

目的:观察静脉滴注rhBNP对ACS患者神经内分泌的影响。方法:选ACS患者,随机分为rhBNP组25例静脉注射rhBNP;对照组25例硝酸甘油治疗。测两组治疗前后BNP水平、肾素、血管紧张素Ⅱ、醛固酮水平。结果:治疗后48h、5d、7d两组BNP较治疗前均降,rhBNP组降大于对照组,rhBNP组峰值显著低于对照组(P<0.05);治疗后36h rhBNP组血浆肾素、血管紧张素Ⅱ、醛固酮较治疗前降程度显著大于对照组(P<0.05),对照组治疗前后差异无统计学意义(P>0.05)。结论:ACS早期静脉注射rhBNP可降低肾素、血管紧张素Ⅱ、醛固酮、BNP水平,抑制神经内分泌系统的激活。

Objective： To observe the intravenous drip rhBNP right neuroendocrine effects in patients with ACS. Methods ACS patients, 25 patients were randomly divided into rhBNP intravenous rhBNP; control group, 25 cases of nitroglycerin therapy. BNP levels measured before and after treatment groups, renin, angiotensin Ⅱ, aldosterone levels. Results After treatment, 48h, 5d, 7d two groups of BNP were lower than before treatment, rhBNP group drop than the control group, rhBNP group peak was significantly lower than the control group （P 〈0.05）; the treatment group after 36h rhBNP plasma renin, blood vessels angiotensin Ⅱ, aldosterone levels lower than that before treatment was significantly higher than the control group （P 〈0.05）, the control group before and after treatment was no significant difference （P〉 0.05）. Conclusion ACS can reduce the rhBNP early intravenous injection of renin, angiotensin Ⅱ, aldosterone, BNP levels, inhibit the activation of the neuroendocrine system.