通脑心脉灵对动脉粥样硬化大鼠血脂、MDA的影响

Effect of Tongnaoxinmailing on the Blood Lipid and MDA of Atherosclerosis Rats

目的:通过实验性动脉粥样硬化(AS)大鼠模型,观察中药通脑心脉灵对大鼠血清生化指标的影响。方法:维生素D3灌胃配合高脂饮食建立AS模型。4周后抽查各组大鼠,确定模型成功,各治疗组分别开始灌胃用药。12周后观察各项生化指标。结果:(1)通脑心脉灵能调节血脂。(2)通脑心脉灵显著降低MDA含量。结论:通脑心脉灵有效改善高血脂状态,抑制脂质过氧化,从而对抗动脉粥样硬化的形成。

Objective: To observe the effect of Tongnaoxinmailing on the serum biochemical markers of rats through atherosclerosis rat model experiments.Methods: AS models were made by the gavage of vitamin D3 and high-fat diet.4 weeks later,the models were ascertained to be successful.Each group was given gavage medication.The biochemistrial markers of the rats were observed 12 weeks later.Result: Tongnaoxinmailing can regulate blood lipid disorder and lower the content of MDA obviously.Conclusion: Tongnaoxinmailing can effectively improve the state of high blood lipid,cholesterol,inhibit lipid peroxidation,thus combating the formation of atherosclerosis.