影响先天性甲状腺功能减低症患儿治疗的因素探讨

An Exploratory Study of Factors Influencing Congenital Hypothyroidism Treatment

目的分析河北省先天性甲状腺功能减低症(CH)患儿的治疗情况,探讨促进和妨碍CH患儿进行正规治疗的主要因素,提出相应措施,提高CH患儿的治疗率,促进我省新生儿筛查工作。方法采用查阅病历与问卷调查的方式对我省2000年1月—2008年9月在河北省11所市新生儿筛查中心确诊的CH患儿的治疗情况及各种可能的影响因素进行调查,将CH患儿按治疗情况分成治疗组和放弃组,进行单因素和多因素Logistic逐步分析。结果单因素分析显示:两组患儿的父母文化程度、父母职业、家庭住址、家庭月收入、父母对疾病的认知程度间差异有统计学意义(P<0.05)。多因素Logistic逐步回归分析显示:父母对疾病的认知程度对CH患儿治疗的影响有统计学意义(P<0.05)。结论父母对疾病的认知程度是影响家庭是否对患儿进行治疗的决定性因素,应针对以上因素采取有效措施,提高CH患儿的治疗率,减少残疾的发生,提高人口素质。

Objective To explore the major factors that influence congenital hypothyroidism （CH） treatment.Methods Totally 618 CH children who were treated in our center from January 2000 to September 2008 were divided into treatment group and give-up group based on there therapeutic conditions.Their parents were surveyed with questionnaires.All data were statistically analyzed.Results Parents＇ education background,career,residential area,monthly income,and awareness of CH were significantly different between these two groups.The parents＇ knowledge to CH significantly influenced the treatment outcomes.Conclusion Parents＇ knowledge to CH is a decisive factor of CH treatment.Efforts should be made to increase their awareness and knowledge of this disease to increase treatment rate and reduce mobility and disability rate.