小儿36例复发及慢性过敏性紫癜临床分析

Clinical Analysis of 36 Children with Recurrent and Chronic Henoch-schonlein Purpura

目的分析小儿复发及慢性过敏性紫癜的临床特点及预后。方法回顾性分析皮疹复发及慢性组、肾炎复发及慢性组及普通对照组过敏性紫癜患儿的临床特点,并比较3组患儿紫癜性肾炎的临床分型及预后。结果3组患儿持续性皮疹、严重腹痛、肾炎的症状与体征发生率比较差异均有统计学意义(P<0.05);3组患儿紫癜性肾炎临床类型的构成及预后分级比较,差异均无统计学意义(P>0.05)。结论对于年龄超过9岁、严重腹痛、持续性皮疹、肾炎者,转为复发及慢性过敏性紫癜的可能性较大,应积极寻找诱因,多方面综合治疗,以防止病情进一步加重。

Objective To analyze the clinical characteristics and prognosis of recurrent and chronic Henoch-Schonlein purpura （HSP）in children.Methods A retrospective analysis was conducted on the clinical characteristics of children with recurrent and chronic HSP who were divided into groups A （with recurrent and chronic rashes）,B （with recurrent and chronic nephritis）,C （normal control）.The clinical typings and prognoses were compared between 3 groups.Results There was significant difference in persistent rash,severe abdominal pain,nephritis symptom and sign between 3 groups （P〈0.05）,but there was not in clinical type composition and prognosis classification of Henoch-Schonlein nephritis （P〉0.05）.Conclusion Children 9 years old with severe abdominal pain,persistence rash,nephritis are more likely to have recurrence and chronic HSP.Measures should be taken actively to find predisposing factors and perform comprehensive treatment to prevent deterioration.