血清转铁蛋白与C反应蛋白在新生儿黄疸中的临床应用

Clinical Application of Serum Transferrin and C-reactive Protein in Neonatal Jaundice

目的探讨血清转铁蛋白(TRF)、C反应蛋白(CRP)在新生儿黄疸类型鉴别和疾病演变中的临床价值。方法选择82例高胆红素血症患儿为研究对象,按总胆红素水平分为轻、中、重度黄疸,又按新生儿黄疸的原因将患儿分为感染因素组、围产因素组及其他因素组,另选择同期41例正常新生儿为正常对照组。分别检测TRF、CRP水平,比较各组间有无差异。结果(1)轻、中度黄疸组患儿TRF、CRP水平与正常对照组比较,差异均有统计学意义(P<0.05);重度黄疸组与对照组比较,差异有统计学意义(P<0.05)。(2)感染因素组患儿TRF、CRP水平与正常对照组比较,差异均有统计学意义(P<0.05);围产因素组、其他因素组与对照组比较,差异均有统计学意义(P<0.05);感染因素组与围产因素组、其他因素组比较,差异均有统计学意义(P<0.05)。结论(1)感染因素导致的黄疸,CRP水平明显增高,而TRF水平明显下降。(2)血清TRF和CRP水平对帮助新生儿黄疸的病因鉴别和疾病演变有一定的临床价值。

Objective To investigate the clinical value of serum transferrin （TRF） and C-reactive protein （CRP） in the type identification and evolution of neonatal jaundice.Methods Eighty-two hyperbilirubinemia neonates were divided according to total bilirubin level into groups mild,moderate,severe,and according to the reasons for neonatal jaundice into groups infection factor （IF）,perinatal factor （PF）,other factor （OF）.Another 41 normal newborns were enrolled as control group.The levels of TRF and CRP were detected.Results Groups mild,moderate were significantly different from control,group severe from control in TRF and CRP levels （both P〈0.05）.There was significant difference in TRF,CRP levels between groups IF and control （P〈0.05）,between groups PF,OF and group control （P〈0.05）,between IF group and groups PF,OF （P〈0.05）.Conclusion Infection factors cause jaundice,CRP level increases but TRF level decreases.Serum TRF and CRP levels are of some clinical value in identifying causes of neonatal jaundice and its evolution.