乳腺癌组织中CD_(24)和雌激素受体蛋白表达的相关性研究

Study on Correlation of CD_(24) and Estrogen Receptor in Breast Cancer Tissue

目的探讨乳腺癌组织中CD24和雌激素受体(estrogen receptor,ER)蛋白表达及其相关性。方法对2007年7月至2009年8月在淮南新华医疗集团第二矿工医院被确诊为乳腺癌,并行手术治疗的43例患者的乳腺癌组织标本,采用免疫组织化学法检测CD24和雌激素受体表达情况,并对二者检测结果进行相关性分析。结果乳腺癌组织中,雌激素受体阳性率为69.8%。其中,雌激素受体表达的阳性强度(+)、(++)和(+++)分别为32.6%,20.9%和16.3%;乳腺癌组织中,CD24的阳性率为74.4%。其中,CD24的阳性强度(+)、(++)和(+++)分别为32.6%,23.3%和18.6%;雌激素受体表达程度不同的乳腺癌组织中,CD24的表达程度比较,差异亦有显著意义(χ2=38.696,P=0.001),乳腺癌组织中,雌激素受体和CD24的表达,具有线性趋势关系(χ2=23.258,P=0.001)。结论乳腺癌中,CD24和雌激素受体表达有一定的相关性,CD24的表达随着雌激素受体表达强度增加而逐步增加。联合检测CD24和雌激素受体对患者预后评价,可能更具有临床价值。

Objective To explore the protein expression and correlation of CD24 and estrogen receptor （ER） in breast cancer. Methods From July 2007 to August 2009, 43 cases who diagnosed as breast cancer were admitted to the Second Miner Hospital of Huainan Xinhua Medical Group. The expression of CD24 and estrogen receptor were detected by immunohistochemistry mothod in 43 cases of breast cancer specimens, furthermore, detected results were submitted to correlation analysis. Results The positive rate of estrogen receptor were 69.8% in breast cancer tissues, and the rates of （＋）, （＋＋）, （ ＋＋＋ ） were 32. 6%, 20. 9% and 16.3%. The positive rates CD24 were 74. 4% in breast cancer tissues with the rates of （＋）, （＋＋） and （＋＋＋） being 32.6%, 23.3% and 18.6%. The statistical significance was observed in breast cancer tissues with CD24 being expressed differently in the tissues with the estrogen receptor expressed differently. The expression of CD24 enhanced with expression intensity of estrogen receptor in breast cancer tissues（x^2 =23. 258,P=0. 001）. Conclusions There are positive correlation between the expression of CD24 and estrogen receptor in breast cancer tissues, and the CD24 expression increased with the estrogen receptor expression. Additionally, the combination detection of CD24 and estrogen receptor should be helpful in evaluation of cancer prognosis.