星状神经节阻滞对细胞免疫功能的影响:兼论维生素B的作用

INFLUENCE OF STELLATE GANGLION BLOCK ON CELLULLAR IMMUNITY

目的：观察利多卡因和维生素Ｂ类星状神经节阻滞对红细胞及ＮＫ细胞免疫功能的影响。方法：选择交感型和／或椎动脉型颈椎病病人２４例，随机分为４组，用不同药物行单侧星状神经节阻滞，每日一次，两侧交替，共７天。并于阻滞前，阻滞后３０分钟及７天后取外周血测定红细胞Ｃ３ｂ受体花环率，红细胞免疫复合物花环率和ＮＫ细胞活性。结果：ＬＶＢ（利多卡因＋ＶＢ６＋ＶＢ１２）组和ＬＮＳ（利多卡因＋ＮＳ）组可显著提高红细胞免疫功能，但同时抑制ＮＫ细胞活性，以前者为著；ＶＢ（ＶＢ６＋ＶＢ１２）组及ＮＳ组对上述细胞免疫功能均无明显影响。结论：在星状神经节阻滞对细胞免疫功能的影响中，局麻药（利多卡因）的阻滞起到了关键作用。

Aim: This work was carried out to study the influence of stellate ganglion block(SGB) with different drugs on cellular immunity. Methods: 24 adult patients with sympathetic and/or vertebral arterial type spondylosis were selected. They were randomly divided into 4 groups and received SGB once a day for 7 days by the route of paratrachea. The rosette rate of red blood cell C 3b receptor (RBC C 3b R) and red blood cell immune complex (RBC IC) as well as the activity of NK cell were measured respectively before and after SGB. Results: group LVB (lidocaine+vitamin B) and LNS (lidocaine+normal saline) significantly enhance the cellular immunity, Group LVB inhibit the NK cell activity simultaneously. Group VB and NS have no obvious effects on the cellullar immunity. Conclusion: Local anesthetic (lidocaine) plays a critical role in the effect of SGB on the cellular immunity. The vitamine B 6 and B 12 seem not necessary in this regard. The depressive effect on NK cell activity should be paid attention to during the clinical use.