摘要
用小鼠观察了氯胺酮（Ｋｅｔａｍｉｎｅ，Ｋ）对吗啡（Ｍｏｒｐｈｉｎｅ，Ｍ）镇痛作用及其耐受性的影响。小鼠热板法、电刺激法和扭体法表明，Ｋ（ｉｐ或ｓｃ２０ｍｇ／ｋｇ）在这三种方法中均可增强Ｍ的镇痛作用（Ｐ＜０．０１，Ｐ＜０．０５）。每隔６小时ｉｐＫ２０ｍｇ／ｋｇ，可抑制小鼠对连续注射Ｍ镇痛效应耐受性的形成（Ｐ＜０．０１，Ｐ＜０．０５）。结果提示，Ｋ可增强Ｍ镇痛作用，延缓Ｍ镇痛耐受性的形成，Ｋ与Ｍ没有明显交叉耐受性。Ｋ与Ｍ配伍用于镇痛可能是有益的。
The effects of ketamine(k) on morphine(M) induced analgesia and tolerance were studied by hot plate, electrical stimulation and writhing test in mice. Administration of a combination of K(ip or sc 20mg/kg)and M was found to increase the analgesic effect in the three test(P<0.01,P<0.05). Analgesic effects of both K and M remarkably diminished after 4 repeated administrations,but the administration of the two drugs combined could improve analgesic effect.Tolerance to M induced analgesic effect was inhibited by repeated administration of K(20mg/kg ip, q6h). Cross tolerance between K and M was not observed. These results suggest that administration of a combination of K and M may be benefical in analgesic use.
出处
《中国疼痛医学杂志》
CAS
CSCD
1998年第4期217-221,共5页
Chinese Journal of Pain Medicine
基金
江苏省教委自然科学基金
关键词
氯胺酮
镇痛
耐受性
交叉耐受性
吗啡
Ketamine
Morphine
Analgesia
Tolerance
Cross tolerance
