口服氯胺酮的镇痛及其它作用的实验性研究

ANALGESIA AND OTHER EFFECTS OF ORAL KETAMINE IN THE ANIMAL EXPERIMENTS

为研究口服注射用氯胺酮镇痛效果和慢性毒性反应，本文采用小白鼠扭体法和热板法进行氯胺酮口服的实验研究。结果表明，口服氯胺酮对醋酸所致小白鼠腹腔疼痛有显著的减轻作用，在１０～４０ｍｇ／ｋｇ范围内呈剂效关系。对热刺激足底所致小白鼠疼痛也能提高其痛阈值，在４０～１００ｍｇ／ｋｇ范围内呈剂效关系。大鼠连续口服氯胺酮（剂量为２０、４０、８０ｍｇ／ｋｇ）９０天的慢性毒性试验表明：健康存活，体重增加，血常规、ＥＣＧ、肝、肾功能无异常，脑、肝、肾、心。

To investigate the analgestic effects and chronic toxicity of orally administered ketamine, writhing test and hot plate assays were used in mice in this study. The results indicated that the pain caused by acetic acid (ip.) were effectively relieved by oral administrtion of ketamine (10～40mg/kg), and the pain threshold to hot plate test increased significantly (40～100mg/kg). The studies of the toxicity of ketamine by oral administrtion were carried out in 3 experimental groups(20、40、 80mg/kg) for 90 days. No abnormality was observed (including weight gain, the blood test, as well as hepatic and renal functions). Pathologic examinations of the tissues from brain, liver, kidney and lung showed no differences between the experimental and control groups.