摘要
目的探讨Ⅰ,Ⅱ期非霍奇金淋巴瘤(non-Hodgkin'slymphoma,NHL)综合治疗的有效方法。材料与方法1987年1月~1989年12月收治NHL152例,分别采用单纯放疗、放疗+化疗、化疗+放疗+化疗、化疗+放疗和单纯化疗治疗。结果Ⅰ期NHL分别采用单纯放疗和放、化综合治疗者,其3,5,7年生存率与复发率相近。而Ⅰ期仅有结内受累者,其3,5,7年生存率单纯放疗组分别为100.0%,100.0%,88.9%,放、化综合治疗组分别为88.2%,82.4%,52.9%,单放组生存率较高,而复发率两组相近;Ⅱ期NHL,放、化综合治疗组3,5,7年生存率较单纯放疗组稍高,复发率两组相近,其中高度恶性病例,化疗+放疗+化疗组3,5,7年生存率分别为73.3%,73.3%,60.0%,较放疗+化疗、化疗+放疗组均高,而复发率较低。结论(1)Ⅰ期NHL仅有结内受累者可考虑用单纯放疗。(2)Ⅱ期高度恶性NHL推荐化疗+放疗+化疗方法。
Purpose To seek effective combination therapy for patients with stageⅠand Ⅱ non Hodgkin's lymphoma (NHL). Materials and Methods One hundred and fifty two patients with stageⅠand Ⅱ NHL were treated from January 1987 to December 1989. The methods of treatment included radiation alone, radiation with chemotherapy, chemotherapy followed by radiation then with chemotherapy, chemotherapy with radiation and chemotherapy alone. Results The 3 , 5 , 7 year survival rates and relapse rates were similar for patients with stage ⅠNHL either treated by radiation alone or radiation combined with chemotherapy .For patients with involvement of lymph node alone , the 3 , 5 , 7 year survival rates were 100.0%, 100.0%, 88.9% in radiation alone group and 88.2%, 82.4%, 52.9% in radiation combined with chemotherapy group. The former gave the better results. For patients with stage Ⅱ NHL, the 3 , 5 and 7 year survival rates were slightly higher in radiation combined with chemotherapy group than in radiation alone group , but the relapse rates were similar in both groups . Patients with high grade malignancy as treated by radiation combined with chemotherapy were divided into R+C, C+R+C and C+R group. The 3 , 5 and 7 year survival rates were 73.3%, 73.3%, 60.0% in group C+R+C which were better than in R+C and C+R group. Conclusion For patients with stage ⅠNHL, radiation alone can be used for patients with involvement of lymph node alone. We recommend combination therapy of C+R+C for patients with high grade stage ⅡNHL.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
1998年第4期206-209,共4页
Chinese Journal of Radiation Oncology