1,2,3-O-三乙酰基-5-脱氧-D-呋喃核糖的合成研究

Synthesis of 1,2,3-tri-O-acetyl-5-deoxy-D-ribofuranose

以D-核糖为原料,经过酯化、碘化、还原、水解和乙酰化等步骤合成标题化合物,并探索了一种成本低廉的5位脱氧方法。反应总收率为14.9%。

D-Ribose,as the starting material,was subjected to esterification,iodination,reduction by Raney Ni,hydrolysis and acylation to give 1,2,3-tri-O-acetyl-5-deoxy-D-ribofuranose in an overall yield of 14.9%,leading to the development of a cheap method for deoxygenation of C5.