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辛伐他汀对人脐静脉内皮细胞ABCA1表达的影响 被引量：1

The Effect of simvastatin on the expression of ABCA1 in Human umbilical vein endothelial cells
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摘要 目的研究辛伐他汀对人脐静脉内皮细胞的三磷酸腺苷结合盒转运体A1(ABCA1)表达的影响。方法体外培养人脐静脉内皮细胞,并分别与BSA(对照组)及1、10μmol/L的辛伐他汀组温育24h。采用逆转录聚合酶链反应、流式细胞技术分别检测人脐静脉内皮细胞的ABCA1的mRNA及蛋白表达水平。结果随着给药浓度的增加,人脐静脉内皮细胞的ABCA1表达逐步升高,与对照组比较差异有统计学意义(P<0.05)。结论辛伐他汀的调脂途径可能与其上调人脐静脉内皮细胞的ABCA1表达有关。 Objective To study the effect of simvastatin on the expression of ATP-binding cassette transporter A1（ABCAl）in human umbilical vein endothelial cells（HUVECs）.Methods The HUVECs were cultured in vitro and incubated with simvastatin at different concentrations（0μmol/L,1μmol/L,10μmol/L）for 24h,and ABCA1 expression levels were determined by RT-PCR and flow cytometry.Results Simvastatin increased ABCA1 expression in HUVEC in a concentration-dependent manner（P0.05）.Conclusion Simvastatin increases ABCA1 expression in HUVECs,which is related to its lipid lowering properties.
作者 刘芃 李公信 刘映峰 吕俊豪 缪绯 徐琳 赵欢
机构地区 南方医科大学珠江医院心血管内科 广州军区广州总医院心血管内科
出处 《广东医学》 CAS CSCD 北大核心 2010年第4期416-418,共3页 Guangdong Medical Journal
基金 广东省科技计划资助项目(编号:2007B031507001)
关键词 三磷酸腺苷结合盒转运体A1 胆固醇流出 辛伐他汀 动脉粥样硬化 ATP-binding cassette transporter A1 cholesterol efflux simvastatin atherosclerosis
分类号 R285.5 [医药卫生—中药学]
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参考文献9

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二级参考文献19

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共引文献7

同被引文献19

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二级引证文献2

广东医学
2010年 第4期

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