经络穴位经皮给药系统的机制研究

Discussion on the Mechanism of Medicinal Offering System through Skin of Acupoints

内服及注射用药以外，通过皮肤给药正引起国内外医学界的极大关注。利用皮肤作为药物输入体循环的门户，发挥药物的治疗作用，是对传统给药观念的重要突破。临床实践证明经皮给药系统优点甚多。例如：避免肝脏的“首过效应”，避免药物在胃肠道的破坏，减少血药浓度峰谷变...

The medicinal offering system through skin of acupoints,which comes from the meridian and channel theory of TCM,includes the two characteristics of acupoints effection and medicinal effection.The authors studied the mechanism and found that it was associated with three factors:the character of outer sensitivity of acupoints,biological activated character of Chinese herbs and enlarging effection of acupoints,and the variation of ultrastructure of local skin.The authors also predicted that the special medicine offering system would be quite useful in treating tumor and other chronic diseases.