干扰素联合拉米夫定治疗对合并活动性肝炎肝癌术后复发的影响

The influence which the interferon unites the Lami husband to decide the treatment after merge activity hepatitis liver cancer technique recurs

目的：观察拉米夫定结合干扰素治疗对合并活动性肝炎肝癌术后复发的影响。方法：27例合并活动性肝炎的肝癌患者随机分为两组：对照组14例，为单纯手术切除；治疗组13例，为手术切除联合术后拉米夫定加干扰素治疗。观察两组的乙型肝炎病毒DNA（HBV—DNA）清除率、乙型肝炎e抗原（HBeAg）转阴率、复发时间和生存时间。结果：治疗组和对照组比较，1年后HBV—DNA清除率分别为100．0o,4和5．8％（P〈O．01）。HBeAg转阴率分别为60．5％和5．5％（P〈0．05），1年肿瘤复发率分别为76．9％和92．8％（P〉0．05），中位复发时间分别为6．8个月和4．5个月（P〈0．01），中住生存时间分别为9．5个月和6．5个月（P〈0．01）。结论：拉米夫定结合干扰素治疗有助于合并活动性肝炎的肝癌患者术后清除病毒复制，延迟肿瘤复发，提高患者生存时间。

Objective：The influence which observes the Lami husband to decide the union interferon treatment after merge activity hepatitis liver cancer technique recurs. Methods： 27 example merge activity hepatitis＇s liver cancer patient divides into two groups stochastically： The control group 14 examples, excise for the pure surgery; The treatment group 13 examples, excises the union technique after the surgery the Lami husband add the interferon treatment surely. Observes two group of hepatitis B virus DNA （HBV--DNA） percentage clearance, hepatitis B e antigen （HBeAg） to transfer cloudy rate, the recrudescence time and the life. Re- suits：Treats the group and the control group comparison, 1 year later the HBV--DNA percentage clearance respectively is 100.0 % and 5.8% （P〈0.01）. HBeAg transfers cloudy rate respectively is 60.5% and 5.5%（P〈0.05）, 1 year tumor recurrence rate respectively is 76.9% and 92.8%（P〉0.05） ,the position recrudescence time respectively is 6.8 months and 4.5 months（P〈0.01） , the position life respectively is 9.5 months and 6.5 months （P〈0.01）. Conclusion：The Lami husband decides the union interferon treatment is helpful after the merge activity hepatitis liver cancer patient technique eliminates the viral duplication, retards the tumor recrudescence, enhances the benefit life.