2006年～2009年医院病原菌分布及耐药性分析

Pathogenic bacteria distribution and drug resistance in hospital from 2006 to 2009.

目的分析4年内医院常见感染性病原菌的流行趋势及耐药性变化，为临床抗生素的合理使用提供科学依据。方法常规培养分离鉴定细菌，采用珠海迪尔医学细菌测定系统软件，药敏试验应用MIC法，对2006年～2009年医院感染病原菌进行回顾性分析。结果从2006年～2009共分离出1249株病原菌，其中革兰阴性杆菌783株，占63％，革兰阳性球菌466株，占37％；分离率排前五位的依次是大肠埃希菌、铜绿假单胞菌、金黄色葡萄球菌、白色念珠菌、肺炎克雷伯菌；革兰阴性杆菌和革兰阳性球菌都存在不同程度的耐药，革兰阴性杆菌对亚胺培南最敏感，未发现葡萄球菌对万古霉素耐药，白色念珠菌对两性霉素B较敏感。结论加强对医院常见病原菌的变迁及耐药情况的监测，对指导临床用药具有重要的意义。

Objective To analyse the distribution, drug resistance and epidemiology of pathogenic bacterias in the people＇s hosiptal of Xingguo county during these four years, to provide scientific basis for rational applications of antibacterial drugs. Methods All isolates were identified by DL bacteria indentifying system, drug sensitive tests were conducted with MIC, a retrospective analysis of pathogenic bacteria was performed in the hospital from 2006 to 2009. Results 1 249 strains pathogenic bacterias were isolated from 2006 to 2009, the isolated rates of grant - negative bacterias were 63% （783/1279）, the isolated rates of gram - positive bacterias were 37% （466/1279） ;the top five pathogenic bacterias were Escherichia coil, pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Klebsiella pneumoniae. Drug resistance of varying degree were observed for gram - negative bacterias and gram - positive bacterias. Grant - negative bacterias were most sensitive to Imipenem, staphylococcus were sensitive to Vancomycin, Candida albicans were sensitive to Amphotericin B. Conclusion To strengthen monitor of drug resistance and epidemiology of pathogenic bacterias have important significance in clinical rational use of antimicrobial agents.