黎药胆木不同提取部位急性毒性实验研究

Study on the Acute Toxicity of Different Extractions of Nauclea offcinalis

目的观察胆木不同提取部位的急性毒性。方法以最大浓度及最大给药体积的药液灌胃给药,3次/d。连续观察7 d,记录小鼠毒副反应情况。结果观察7 d后,全部动物健存,小鼠体重平均增长28.14%和21.46%,均未见任何毒性反应。胆木水提物最大给药量为400 g/kg体重,相当于成人日用量的200倍;胆木总生物碱给药量为24 g/kg。结论胆木不同提取部位毒性均较小。

Objective To study the acute toxicity of different extracts of Nauclea offcinalis（DEONO）.Methods The maximum administration dosage of DEONO was determined by ig administration in mice,and three times a day.Its acute toxic reactions were observed for 7 days.Results All mice were survive,and no toxic reaction was shown during the observed period.The average rate of increasing weight of water extract and total alkloids were 28.1% and 21.47%,respectively.The maximum administration dosage（400 g/kg） of water extract was equal to 200 times of men＇s daily administration dosage and the maximum administration dosage of total alkloids was 24 g/kg.Conclusion The DEONO is safe for oral administration.