摘要
目的评价清化方对代谢综合征人群氧化应激水平的作用及可能途径。方法采用随机双盲平行安慰剂对照的方法,通过8周临床观察,比较治疗前后丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)和谷胱甘肽过氧化物酶(GSH-Px)的变化。结果干预前两组BMI、WHR、血压、HbA1c、血脂等指标具有可比性;治疗组血清MDA水平下降,对照组上升(P=0.046);治疗组血清SOD水平下降低于对照组(P=0.038);两组GSH、GSH-Px变化无差异(P>0.05)。结论清化方对于代谢综合征人群具有一定的抗氧化作用,其作用环节与抗氧化酶SOD相关。
Objective To evaluate the antioxidant activities of Qing-Hua decoction in patients with MS.Methods A randomized,double-blind,placebo-controlled test was conducted.Through observations for 8 weeks,we measured changes of serum concentrations of SOD,GSH,GSH-px and MDA between the two groups.Results Before therapy,there were no significant difference in BMI,WHR,blood pressure,HbA1c and blood lipid between groups(P0.05).After 8-week duration,serum level of MDA was decreased in treatment group.But the placebo group was on the other hand(P=0.046).Serum actiuity of SOD was decreased in the two groups,while changes in treatment group was less(P=0.038).There were no significant differences in changes of serum concentrations of GSH and GSH-px between the two groups.Conclusion Qing-Hua decoction can be used as an antioxidant in patients with MS.The efficacy can be resulted to increase of SOD.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第3期680-681,共2页
Lishizhen Medicine and Materia Medica Research
基金
上海市教委科研项目(No.06cz028)
关键词
代谢综合征
抗氧化
清化方
Metabolic syndrome
Antioxidant
Qing-Hua decoction