恶性腹腔积液卡铂腹腔化疗研究

STUDY ON OBDOMINAL CHEMOTHERAPY OF CANCER OF PERITONEAL FLUID

目的：探讨卡铂对恶性腹水腹腔化疗的疗效。方法：恶性腹水患者１０例，采用高效液相色谱法测定。卡铂３００ｍｇ／ｍ２加生理盐水７５０ｍｌ行快速腹腔注射，１６０～１８０ｍｉｎ取腹腔液、门静脉及外周血，２４０～２７０ｍｉｎ取癌组织、癌旁正常组织、腹膜、大网膜、阴性淋巴结测定总铂浓度。结果：腹腔液浓度最高，平均４８．１４ｕｌ／ｍｌ，门静脉次之１０．１ｕｌ／ｍｌ，分别是外周血的８和１．６倍。被测组织中，腹膜浓度超出其它组织浓度（Ｐ＜０．０５），癌组织含量高于正常组织。结论：卡铂腹腔化疗不仅提高腹腔、门静脉药物浓度，而且在腹膜、癌组织内有一定聚积性，对于杀灭腹腔亚临床病灶，改善临床分期，控制医源性转移，提高治愈率发挥重要作用。

Objective:The study of carboplatin was performed with cancer of peritoneal fluid as to discuss clinic effect.Method:The carboplatin cocentration was measured in peritoneal fluid.Partal venous blood and peripheral blood 160～180 minutes affer fast introperitoneal injecplatin concentration was measured in cancer tissue,normal tissue,peritoneum,greater omentum and non metastatic lymph nodes 240～270 minutes after injection.Result:carboplation concentration in peritoneal fluid was the highest with a mean concentration of 48.14 ul/ml.Next to it was the blood of portal vein 10.11ul/ml.These figures were 8 times and 1.6 times as much comparing with the concentration in peripheral blood.The concentration in peritoneum was higher than that of other tissues (P<0.05).The concentration in tumor tissue was higher than that in normal tissues.Conclusion:This study demonstrated that preoperative intraperitoneal chemotherapy of carboplatin not only increased the concentration of carboplatin in peritoneal cavity and portal vein blood,but also accumulated in peritoneum and tumor tissue which would contribute to killing subclinical lesions.