三种天然提取物的减肥降脂作用研究

Effect of three natural ingredients on body weight-reducing and serum lipid-reducing

选用Wistar雄性大鼠,喂饲高脂饲料,建立预防性肥胖高血脂模型,对苦丁茶水提取物、阿拉伯糖、乌龙茶提取物三种天然成分进行减肥降脂试验。大鼠随机分组,灌胃给药,以药物曲美减肥胶囊为阳性对照组。测定模型组、给药实验组、阳性对照组各种生化指标(如总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白)、大鼠的体重、Lee′s指数和脂肪湿重等。结果表明:各给药实验组较模型对照组体重增长减慢,且下降明显,体内脂肪湿重也明显下降,同时发现L-阿拉伯糖组有极其显著降低血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、Lee′s指数和体内脂肪含量(P<0.01)的效果。L-阿拉伯糖对肥胖症、高血脂症具有良好的预防和治疗的作用。

70 male wistar rats were randomly divided into 7 groups according to body weight,and fed with a high fat diet and supplement to set up the model rat of obesity and hyperlipemia. Qumei medicine was used as a positive control,extract of Ku-Ding-Cha,L-arabinose and extract of oolong tea used as experimental controls to investigate their effect on body weight-reducing and secrum lipid-reducing. After continuing administration,the biochemical markers of different groups,including model control,positive control and experimental control were measured. The results showed that comparing with model control,all positive control and experimental controls could reduce the rat＇s body weight. Furthermore,the Lee＇s index,wet weight of fat,total cholesterol（TC）,serum truglyceride（TG）,low density lipoprotein-cholesterol（LDL-C）were significantly decreased in L-arabinose experimental group. So L-arabinose has a good anti-obesity and anti-hyperlipemia effectiveness.