口服乾坤宁治疗甲型H1N1流感的回顾性研究

Retrospective study on the therapy of H1N1-A Influenza with oral Qiankunning

目的评价口服乾坤宁治疗甲型H1N1流感病例的疗效。方法回顾性分析227例接受乾坤宁、达菲、乾坤宁合用达菲或单纯对症治疗的甲型H1N1流感病例的疗效。结果根据入选标准和排除标准共入选112例,其中达菲治疗组仅4例,不予统计学分析。实际纳入分析共108例。使用乾坤宁治疗后,甲型H1N1流感8个主要症状持续时间之和的中位天数为6d,短于对症治疗组的7.5d(P<0.05)。乾坤宁+达菲治疗后流感病毒核酸转阴最快,中位天数为2d,乾坤宁组为3d,无显著性差异(P=0.054);但两组均显著快于对症治疗组的4d(P<0.001,P=0.025)。乾坤宁开始治疗1d后,症状缓解相对较快,23.3%的病例(7/30)症状可完全缓解,而对症治疗组为12%(6/50),但无显著性差异(P>0.05);治疗3d后,70.4%病例(76/108)症状完全缓解,各组间结果类似。结论中药乾坤宁治疗甲型H1N1流感病例,具有抗病毒,缓解症状,快速退热和缩短病程的作用,且无明显不良反应。

Objective To evaluate the efficacy of therapy with oral Qiankunning for patients with H1N1-A Influenza infection.Methods 108 patients with H1N1-A Influenza infection were recruited and divided into three groups by different therapy：treatment with Qiankunning,combination therapy with Qiankunning and Oseltamivir,and symptomatic treatment.A retrospective study was performed to evaluate the efficacy of these three treatments.Results The median of duration of 8 symptoms in patients with Qiankunning therapy （6,ranged from 2 to 40） and combination therapy （6,ranged from 1 to 21） were significantly shorter than that in patients with symptomatic treatment （7.5,ranged from 1 to 25）,（P〈0.05）.The median of virus shedding were 2 days （from 1 to 4） in patients using combination therapy with Qiankunning and Oseltamivir and 3 days （1-5days） in patients treated with Qiankunning,shorter that that in patients with symptomatic treatment （4 days,from 2 to 7days）,（P 〈0.001,P=0.025,respectively）.The frequency of symptoms remission in the patients with Qiankunning therapy was 23.3% （7/30） after 1 day therapy,better than that in patients with symptomatic treatment （12%,6/50）,and after 3 days therapy,70.4% （76/108） of patients gained remission in three groups and there was no difference amongst these groups.Conclusions Qiankunning plays an important role in the control of H1N1-A Influenza infection,especially in the control of viral replication,remission of symptoms,lower the temperature and shorter disease progression,and there is no adverse effect found during the therapy.